Upon application to the decayed surface, a layer of silver protein congugates and silver minerals
forms, increasing resistance to acid dissolution and enzymatic digestion. Hydroxyapatite and
fluorapatite form. The treated lesion increases in mineral density and hardness. The silver acts as
an antimicrobial, the fluoride acts to remineralize and the proteins that break down the dentin are
inhibited. The ammonia acts as a stabilizer, keeping silver and fluoride ionic in solution. SDF will
always discolor anything with exposed collagen, meaning it will stain decayed or demineralized
sites and soft tissues, but not healthy tooth structure.
• Now tinted (blue), for an easier application!
• Cost-efficient : ± $0.92 (1 drop) to ± $1.84 (2 drops) for 5 surfaces*
• 8ml bottle = 250 drops
• Each drop = Up to 5 surfaces
• Dental hygienists and dental assistants can apply it
• Increases resistance to acid dissolution11
• Increases mineral density and hardness while the lesion depth decreases5
• No post-treatment limitations
*Based on an 8ml bottle at 220$
• Outperforms other anti-caries treatments in killing cariogenic bacteria15
• Quick application (less than 5 minutes)
• User-friendly, no need for:
• Air or water
How deep does it penetrate?
~ 25-30 microns into enamel
~ 200-300 microns into dentin
~ up to 2mm into a deep lesion
• Alternative to restorative treatment
• Around margins of lesions to prevent secondary decay
• Avoid general anesthesia or oral sedation
• Behavioral or medical management
• Carious lesions that cannot be treated in 1 visit
• Difficult access to dental care
• Difficult to treat dental carious lesions
• High risk caries
• Behavioral or medical management patients
• Carious lesions that cannot be treated in one visit
• Difficult to treat lesions
• High risk caries
• Root caries
• Tooth sensitivity
Arrests the progress of an already formed cavity in permanent or primary teeth.
Before application: take care of your patient
Show them the consent form, inform them of the staining and protect their eyes.
For Silver Diamine Fluoride treatment without restoration placement:
1. Isolate the affected area with a cotton roll or dri-angle.
2. Dry the lesion or surface.
3. Dispense 1 drop into a disposable dish (1 drop treats up to 5 tooth surfaces).
4. Apply Advantage Arrest to the lesion of tooth surface.
5. Allow it to soak in for 60 seconds. This is the most critical step in the process.
6. Remove excess with a cotton pellet or roll and then cover the treated area with a thin layer of fluoride varnish (FluoriMax).
This will create a barrier and keep the silver in contact for as long as possible.
It will also give your patient a nice flavor in their mouth rather than the metallic taste of SDF.
7. If no varnish is applied, let it dry completely for 60 seconds.
8. Repeat again in 1-3 weeks for highest chance of arresting the lesion.
9. To optimize caries arrest, reapply once at intervals of every 6 months OR apply a Glass Ionomer over top to seal out the nutrient source for any bacteria to survive under the restoration.
10. There are no post op patient instructions.
For Silver Diamine Fluoride treament with restoration placement:
1. Isolate the affected area with a cotton roll or dri-angle.
2. Dry the lesion or surface.
3. Dispense 1 drop of Adavantage Arrest into a disposable dish
(1 drop treats up to 5 tooth surfaces).
4. Apply Advantage Arrest to the lesion of tooth surface.
5. Allow it to soak in for 60 seconds. This is the most critical step in the process.
6. Rinse and dry the treated area.
7. Proceed with your restorative steps for the material type you are using. To reduce blackening of the filling:
• Polish away discoloration along the margins.
• Do not use a light cure step, use a self cure Gl, or “sandwich” of opaque GI at deeper
levels and then composite
(If you light cure Advantage Arrest, all of the silver will oxidize even on non-decayed
surfaces and your filling can appear dark).
8. There are no post op patient instructions. Interproximal Decay
Interproximal decay can be treated using a Superfloss Technique (see video).
Direction for use for children 0-3 years old
Maximum of 1 drop per 10 kg of bodyweight per treatment visit 3.
Staining is an indicator of antimicrobial effectiveness.
The functional indicator of effectiveness is when the silver oxide is
bound to the diseased collagen and intrinsic pigmentation of a carious
lesion occurs. These oxides don’t polish away because the blackened
lesion retains its dark color for a long period, which is why the antimicrobial
effect is long lasting.
SDF stains demineralized areas and soft-tissues. Stains can be
reduced by gentle polishing with tincture of weak iodine solution
or by being covered with Glass Ionomer.
The staining is not immediate but will be noticed within hours. It will be
limited to direct areas of contact. For soft-tissue, it will fade over a
period of 24 to 72 hours.
SDF does not stain sound or healthy enamel or dentin. SDF stains clothing, counters, floors and instruments.
Example of application
Black mat is an indicator that the lesion is static.
History of silver diamine fluoride
1870-1912: SDF IS USED FOR 80 YEARS AS A CARIES-ARRESTING AGENT IN ASIA
Ohaguro, a custom of dyeing one's teeth black, was practiced in Japan and other countries. It was also beneficial, as it prevented tooth decay.
2014: ADVANTAGE ARRESTTM IS CLEARED BY THE U.S. FDA
Advantage Arrest is cleared by the U.S. Food & Drug Administration (FDA) for dentinal hypersensitivity.
2015: ADVANTAGE ARRESTTM IS AVAILABLE IN THE U.S.
Advantage Arrest is commercially available in the United States through Elevate Oral Care, LLC.
Since then, it has been used extensively by oral health professionals in the U.S., off-label for the arrest of tooth decay.
2016: GRANTED THE FDA BREAKTHROUGH THERAPY DESIGNATION FOR THE ARREST OF TOOTH DECAY
Advantage Arrest is granted the 1st Breakthrough Therapy Designation by the FDA for an oral care product. This designation represents the
FDA’S effort to address an unmet, serious, life-threatening medical need where there is no available therapy and to expedite the review of such
products. The designation was granted based on the FDA review of 10 worldwide randomized clinical trials evaluating silver diamine fluoride for
caries arrest in children aged 3-9 or adults aged 60-89. Collectively these trials involved 1,500 subjects who were monitored for 1-3 years.
2016: THE NEW YORK TIMES PUBLISHES AN ARTICLE ON SDF
Advantage Arrest is the subject of hundreds of lectures, online posts and articles. It is featured on major consumer media outlets including the New York Times, which published a whole story entitled “A Cavity-Fighting Liquid Lets Kids Avoid Dentists’ Drills”.
2017: ADVANTAGE ARRESTTM IS APPROVED BY HEALTH CANADA
Advantage Arrest is granted the Health Canada indication of an anti-caries agent.
Just got back from the ASM (2017) last week where I ordered my first bottle of Advantage Arrest from Oral Science. By far my favourite company for quality products. This product enables you to arrest those "suspicious lesions". I can't see how this wouldn't be beneficial for every IRDH!
- Heather Wolframe, owner of Go Smile practice
My daughter, age 4, had a successful application of silver diamine fluoride (SDF) in Calgary to arrest decay in her primary molars.
Even though I ensured limiting sugar intake, eating healthy homemade meals and following a strict dental hygiene, I was shocked when decay was diagnosed in her one tooth, and six months after that three other teeth were affected too.
I was thrilled when I found out that Health Canada approved SDF for caries treatment under the product name Advantage Arrest, which is distributed by Oral Science.
Our pediatric dentist has just ordered SDF product and I was happy we were able to try it with amazing early results. The decay was treated and arrested in all four teeth. The SDF application was easy; all four teeth were treated in 5-7 minutes. No tears, no fear, only smiles and a gift to take - the part my daughter enjoys the most.
I believe it can truly revolutionize the dental care in young patients.
1. Aust Dent J. 2015 Mar;60Suppl 1:95-105. doi: 10.1111/adj.12288. Improving the oral health of frail and functionally dependent elderly. Lewis A(1), Wallace J, Deutsch A, King P.
2. Aust Dent J. 2015 Mar;60(1):80-7. doi: 10.1111/adj.12276. Effect of silver diamine fluoride and potassium iodide on residual bacteria in dentinal tubules. HamamaH(1), Yiu C, Burrow M.
3. Int J Antimicrob Agents. 2015 Feb;45(2):183-7. doi: 10.1016/j.ijantimicag.2014.09.007. Epub 2014 Oct 14.Action of silver nanoparticles towards biological systems: cytotoxicity evaluation using hen's egg test and inhibition of Streptococcus mutans biofilm formation. FreirePL(1), Stamford TC(2), Albuquerque AJ(3), Sampaio FC(3), Cavalcante HM(3), Macedo RO(3), Galembeck A(4), Flores MA(5), Rosenblatt A(6).
4. Trials. 2014 Nov 19;15:448. doi: 10.1186/1745-6215-15-448. New proposal of silver diamine fluoride use in arresting approximal caries: study protocol for a randomized controlled trial. Mattos-Silveira J, Floriano I, Ferreira FR, Viganó ME, Frizzo MA, Reyes A, Novaes TF, Moriyama CM, Raggio DP, Imparato JC, Mendes FM, Braga MM(1).
5. Int J Pediatric Dent. 2014 Sep 17.doi: 10.1111/ipd.12134. [Epub ahead of print] Children's discomfort may vary among different treatments for initial approximal caries lesions: preliminary findings of a randomized controlled clinical trial. Mattos-SilveiraJ(1), Floriano I, Ferreira FR, Viganó ME, Mendes FM, Braga MM. Author information:
6. J Dent. 2014 Aug;42(8):945-51. doi: 10.1016/j.jdent.2014.05.017. Epub 2014 Jun 12. A new "silver-bullet" to treat caries in children--nano silver fluoride: a randomized clinical trial. Santos VE Jr(1), VasconcelosFilho A(2), Targino AG(3), Flores MA(4), Galembeck A(5), Caldas AF Jr(6), Rosenblatt A(7).
7. J Mater Sci Mater Med. 2014 Aug;25(8):2041-7. doi: 10.1007/ s10856-014-5221-5. Epub 2014 May 13.An innovative approach to treating dental decay in children. A new anti-caries agent. TarginoAG(1), Flores MA, dos Santos Junior VE, de Godoy BenéBezerra F, de Luna Freire H, Galembeck A, Rosenblatt A.
8. Lasers Med Sci. 2015 Apr;30(3):985-91. doi: 10.1007/ s10103-014-1521-8. Epub 2014 Jan 26.Effect of laser irradiation on the fluoride uptake of silver diamine fluoride treated dentine. Mei ML(1), Ito L, Zhang CF, Lo EC, Chu CH.
9. BMC Res Notes. 2014 Jan 3;7:3. doi: 10.1186/1756-0500-7-3. Arresting rampant dental caries with silver diamine fluoride in a young teenager suffering from chronic oral graft versus host disease post-bone marrow transplantation: a case report. Chu CH(1), Lee AH, Zheng L, Mei ML, Chan GC.
10. J Dent. 2014 Apr;42(4):395-402. doi: 10.1016/j.jdent.2013.12.007. Epub 2013 Dec 25. An ex vivo study of arrested primary teeth caries with silver diamine fluoride therapy. Mei ML(1), Ito L(1), Cao Y(2), Lo EC(1), Li QL(3), Chu CH(4).
11. BMC Oral Health. 2013 Dec 28;13:73. doi: 10.1186/1472-6831-13-73. Clinical evaluation of a modified silver fluoride application technique designed to facilitate lesion assessment in outreach programs. Craig GG(1), Powell KR, Price CA.
12. Indian J Dent Res. 2013 Sep-Oct;24(5):575-81. doi: 10.4103/0970-9290.123374. Efficacy of silver diamine fluoride as an antibacterial as well as anti plaque agent compared to fluoride varnish and EOC 5030, Rev 05 03/01/16 acidulated phosphate fluoride gel: an in vivo study. Shah S(1), Bhaskar V, Venkataraghavan K, Choudhary P, Ganesh M, Trivedi K.
13. J Dent. 2014 Mar;42(3):329-35. doi: 10.1016/j.jdent.2013.11.018. Epub 2013 Dec 4.The inhibitory effects of silver diamine fluorides on cysteine cathepsins. Mei ML(1), Ito L(1), Cao Y(2), Li QL(3), Chu CH(4), Lo EC(1).
14. Org Lett. 2014 Jan 3;16(1):102-5. doi: 10.1021/ol403083e. Epub 2013 Dec 2.AgF-mediated fluorinativehomocoupling of gem-difluoroalkenes. GaoB(1), Zhao Y, Ni C, Hu J.
15. Science. 2013 Nov 22;342(6161):956-60. doi: 10.1126/science. 1243759. Selective C-H fluorination of pyridines and diazines inspired by a classic amination reaction. FierPS(1), Hartwig JF.
16. Nat Protoc. 2013 Dec;8(12):2348-54. doi: 10.1038/nprot.2013.144. Epub 2013 Oct 31. Oxidative aliphatic C-H fluorination with manganese catalysts and fluoride ion.Liu W(1), Huang X, Groves JT.
17. J Dent. 2013 Sep;41(9):809-17. doi: 10.1016/j.jdent.2013.06.009. Epub 2013 Jun 27. Inhibitory effect of silver diamine fluoride on dentine demineralisation and collagen degradation. Mei ML(1), Ito L, Cao Y, Li QL, Lo EC, Chu CH.
18. Med Oral Patol Oral Cir Bucal. 2013 Nov 1;18(6):e824-31. Caries arresting effect of silver diamine fluoride on dentine carious lesion with S. mutans and L. acidophilus dual-species cariogenic biofilm. Mei ML(1), Chu CH, Low KH, Che CM, Lo EC.
19. Lasers Med Sci. 2014 Nov;29(6):1785-91. doi: 10.1007/ s10103-013-1329-y. Epub 2013 Apr 26.Prevention of dentine caries using silver diamine fluoride application followed by Er:YAG laser irradiation: an in vitro study. Mei ML(1), Ito L, Chu CH, Lo EC, Zhang CF.
20. Spec Care Dentist. 2013 May-Jun;33(3):133-40. doi: 10.1111/j.1754-4505.2012.00318.x. Epub 2012 Dec 10.Prevention of root caries: a literature review of primary and secondary preventive agents. GluzmanR(1), Katz RV, Frey BJ, McGowan R.
21. Ann ClinMicrobiolAntimicrob. 2013 Feb 26;12:4. doi: 10.1186/1476-0711-12-4. Antibacterial effects of silver diamine fluoride on multi-species cariogenic biofilm on caries.Mei ML(1), Li QL, Chu CH, Lo EC, Samaranayake LP.
22. Aust Dent J. 2013 Mar;58(1):50-6. doi: 10.1111/adj.12033. Epub 2013 Jan 30.An in vitro study of silver and fluoride ions on remineralization of demineralized enamel and dentine. ZhiQH(1), Lo EC, Kwok AC.
23. Caries Res. 2013;47(4):284-90. doi: 10.1159/000346620. Epub 2013 Feb 5.Silver diamine fluoride and education to prevent and arrest root caries among community-dwelling elders. Zhang W(1), McGrath C, Lo EC, Li JY.
24. Contemp Clin Dent. 2012 Jul;3(3):262-4. doi: 10.4103/0976-237X. 103615. Anti-microbial efficiency of silver diamine fluoride as an endodontic medicament -An ex vivo study. Mathew VB(1), Madhusudhana K, Sivakumar N, Venugopal T, Reddy RK.
25. BMC Oral Health. 2012 Dec 31;12:60. doi: 10.1186/1472-6831-12-60. Short term serum pharmacokinetics of diammine silver fluoride after oral application. Vasquez E(1), Zegarra G, Chirinos E, Castillo JL, Taves DR, Watson GE, Dills R, Mancl LL, Milgrom P. EOC 5030, Rev 05 03/01/16
26. Am J Dent. 2012 Oct;25(5):299-302. Changes in the crystallinity of hydroxyapatite powder and structure of enamel treated with several concentrations of ammonium hexafluorosilicate. SugeT(1), Ishikawa K, Matsuo T. 27. BMC Oral Health. 2012 Nov 21;12:52. doi: 10.1186/1472-6831-12-52. Caries preventive efficacy of silver diammine fluoride (SDF) and ART sealants in a school-based daily fluoride toothbrushing program in the Philippines. MonseB(1), Heinrich-Weltzien R, Mulder J, Holmgren C, van Palenstein Helderman WH.
28. J Oral Sci. 2012 Sep;54(3):267-72. Effects of ammonium hexafluorosilicate application on demineralized enamel and dentin of primary teeth. HosoyaY(1), Watanabe E, Tadokoro K, Inoue T, Miyazaki M, Tay FR.
29. Int J Paediatr Dent. 2013 Jul;23(4):279-85. doi: 10.1111/ipd. 12005. Epub 2012 Oct 3. Fluoride and silver concentrations of silver diammine fluoride solutions for dental use. Mei ML(1), Chu CH, Lo EC, Samaranayake LP.
30. Aust Dent J. 2012 Sep;57(3):308-11. doi: 10.1111/j. 1834-7819.2012.01700.x. Epub 2012 May 23. Clinical evaluation of diamine silver fluoride/potassium iodide as a dentine desensitizing agent. A pilot study. Craig GG(1), Knight GM, McIntyre JM.
31. J Dent. 2012 Nov;40(11):962-7. doi: 10.1016/j.jdent.2012.08.002. Epub 2012 Aug 11. Randomized clinical trial on effectiveness of silver diamine fluoride and glass ionomer in arresting dentine caries in preschool children. ZhiQH(1), Lo EC, Lin HC.
32. In Vivo. 2012 Jul-Aug;26(4):657-64. Effect of three fluoride compounds on the growth of oral normal and tumor cells. AcraAM(1), Sakagami H, Matsuta T, Adachi K, Otsuki S, Nakajima H, Koh T, Machino M, Ogihara T, Watanabe K, Watanabe S, Salgado AV, Bastida NM.
33. J Dent Res. 2012 Aug;91(8):753-8. doi: 10.1177/0022034512452278. Epub 2012 Jun 26. Randomized trial on fluorides and sealants for fissure caries prevention. Liu BY(1), Lo EC, Chu CH, Lin HC.
34. J Evid Based Dent Pract. 2012 Jun;12(2):95-6. doi: 10.1016/ j.jebdp.2012.03.011. Chlorhexidine varnish, sodium fluoride varnish, and silver diamine fluoride solution can prevent the development of new root caries in elders living in senior homes in Hong Kong. NiessenLC(1).
35. J Am Chem Soc. 2012 Jul 4;134(26):10795-8. doi: 10.1021/ja304410x. Epub 2012 Jun 22. Copper-mediated fluorination of aryl iodides. Fier PS(1), Hartwig JF.
36. Oper Dent. 2012 Nov-Dec;37(6):610-6. doi: 10.2341/11-344-L. Epub 2012 May 22. Effect of silver diamine fluoride on microtensile bond strength to dentin. Quock RL(1), Barros JA, Yang SW, Patel SA.
37. Dent Mater. 2012 Aug;28(8):903-8. doi: 10.1016/j.dental. 2012.04.011. Epub 2012 May 12.The inhibitory effects of silver diamine fluoride at different concentrations on matrix metalloproteinases.Mei ML(1), Li QL, Chu CH, Yiu CK, Lo EC.
38. Am J Dent. 2012 Feb;25(1):31-4. Antibacterial activity of ammonium hexafluorosilicate solution with antimicrobial agents for the prevention of dentin caries. Shibata S(1), Suge T, Kimura T, Ishikawa K, Matsuo T.
39. J Dent. 2012 Jul;40(7):531-41. doi: 10.1016/j.jdent.2012.03.009. Epub 2012 Apr 3. Silver EOC 5030, Rev 05 03/01/16 compounds used in dentistry for caries management: a review. PengJJ(1), Botelho MG, Matinlinna JP.
40. J Nanosci Nanotechnol. 2011 Nov;11(11):10063-8. Fabrication and enhanced visible light photocatalytic activity of fluorine doped TiO2 by loaded with Ag. Lin X(1), Rong F, Ji X, Fu D, Yuan C.
41. Aust Dent J. 2012 Mar;57(1):65-70. doi: 10.1111/j. 1834-7819.2011.01641.x. Effect of silver and fluoride ions on enamel demineralization: a quantitative study using micro-computed tomography. Liu BY(1), Lo EC, Li CM.
42. Int Dent J. 2012 Feb;62(1):47-51. doi: 10.1111/j.1875-595X. 2011.00088.x. Paradigm shift in the effective treatment of caries in schoolchildren at risk. Dos Santos VE Jr(1), de Vasconcelos FM, Ribeiro AG, Rosenblatt A.
43. Acta Odontol Latinoam. 2011;24(2):127-31. In vitro antibacterial activity of silver diamine fluoride in different concentrations.de Almeida LdeF(1), Cavalcanti YW, Valença AM.
44. J Calif Dent Assoc. 2011 Oct;39(10):735-41. Prevention-centered caries management strategies during critical periods in early childhood. MilgromP(1), Chi DL.
45. J Conserv Dent. 2011 Jul;14(3):233-6. doi: 10.4103/0972-0707.85796. Remineralizing efficacy of silver diamine fluoride and glass ionomer type VII for their proposed use as indirect pulp capping materials - Part II (A clinical study). SinhaN(1), Gupta A, Logani A, Shah N.
46. J Org Chem. 2011 Oct 21;76(20):8543-8. doi: 10.1021/jo2016168. Epub 2011 Sep 26.Palladium-catalyzed direct ortho C-H arylation of 2-arylpyridine derivatives with aryltrimethoxysilane. Li W(1), Yin Z, Jiang X, Sun P.
47. J Conserv Dent. 2011 Apr;14(2):113-6. doi: 10.4103/0972-0707.82603. An ex vivo study to evaluate the remineralizing and antimicrobial efficacy of silver diamine fluoride and glass ionomer cement type VII for their proposed use as indirect pulp capping materials - Part I. Gupta A(1), Sinha N, Logani A, Shah N.
48. J Dent. 2011 Sep;39(9):612-8. doi: 10.1016/j.jdent.2011.06.008. Epub 2011 Jul 1.Reaction of silver diamine [corrected] fluoride with hydroxyapatite and protein. Lou YL(1), Botelho MG, Darvell BW.
49. Int J Paediatr Dent. 2012 Jan;22(1):2-10. doi: 10.1111/j. 1365-263X.2011.01149.x. Epub 2011 Jun 27. Effects of silver diamine fluoride on dentine carious lesions induced by Streptococcus mutans and Actinomycesnaeslundii biofilms. Chu CH(1), Mei L, Seneviratne CJ, Lo EC.
50. J Org Chem. 2011 Jul 15;76(14):5793-802. doi: 10.1021/jo200966k. Epub 2011 Jun 21. Synthesis of triazafluoranthenones via silver(I)-mediated nonoxidative and oxidative intramolecular palladium-catalyzed cyclizations. Koutentis PA(1), Loizou G, Lo Re D.
51. Med Hypotheses. 2011 Sep;77(3):315-7. doi: 10.1016/j.mehy. 2011.05.002. Epub 2011 May 19.Is a drill-less dental filling possible? QuockRL(1), Patel SA, Falcao FA, Barros JA.
52. J Evid Based Dent Pract. 2011 Mar;11(1):54-5. doi: 10.1016/ j.jebdp.2010.11.011. Topical application of silver diamine fluoride may arrest dental caries. HouptM(1).
53. Org Lett. 2011 Mar 18;13(6):1510-3. doi: 10.1021/ol200196m. Epub 2011 Feb 11.Silver- EOC 5030, Rev 05 03/01/16 mediated palladium-catalyzed direct C-H arylation of 3-bromoisothiazole-4-carbonitrile.IoannidouHA(1), Koutentis PA.
54. J Mol Model. 2011 Sep;17(9):2237-48. doi: 10.1007/ s00894-010-0949-4. Epub 2011 Jan 22.On possible existence of pseudobinary mixed valence fluorides of Ag(I)/Ag(II): a DFT study. Grochala W(1).
55. Anal Chem. 2011 Feb 15;83(4):1315-20. doi: 10.1021/ac1024683. Epub 2011 Jan 14.Quantification of VX vapor in ambient air by liquid chromatography isotope dilution tandem mass spectrometric analysis of glass bead filled sampling tubes. Evans RA(1), Smith WL, Nguyen NP, Crouse KL, Crouse CL, Norman SD, Jakubowski EM.
56. Stat Med. 2011 Feb 10;30(3):250-9. doi: 10.1002/sim.4094. Epub 2010 Nov 5.Analysis of multilevel grouped survival data with time-varying regression coefficients. Wong MC(1), Lam KF, Lo EC.
57. J Dent Res. 2011 Feb;90(2):203-8. doi: 10.1177/0022034510388516. Epub 2010 Nov 30. The short-term effects of diammine silver fluoride on tooth sensitivity: a randomized controlled trial. Castillo JL(1), Rivera S, Aparicio T, Lazo R, Aw TC, Mancl LL, Milgrom P.
58. MolPharmacol. 2010 Nov;78(5):952-60. doi: 10.1124/mol.110.066407. Epub 2010 Aug 20.Inhibition of large-conductance Ca2+-activated K+ channels by nanomolar concentrations of Ag+. Zhou Y(1), Xia X, Lingle CJ.
59. J Dent Res. 2010 Oct;89(10):1086-90. doi: 10.1177/0022034510375825. Epub 2010 Jul 29.A randomized trial on root caries prevention in elders.Tan HP(1), Lo EC, Dyson JE, Luo Y, Corbet EF.
60. Zhongguo Yi XueKeXue Yuan XueBao. 2010 Jun;32(3):265-8. doi: 10.3881/j.issn.1000-503X.2010.03.005. [Effect of combination of pulsed CO2 laser irradiation and diammine silver fluoride treatment on ultrastructure of dentine].[Article in Chinese] Wang Q(1), Zhao JZ, Wu XM.
61. J Endod. 2010 Jun;36(6):1026-9. doi: 10.1016/j.joen.2010.02.029. Epub 2010 Apr 24. Antimicrobial efficacy of 3.8% silver diamine fluoride and its effect on root dentin. HiraishiN(1), Yiu CK, King NM, Tagami J, Tay FR.
62. J Evid Based Dent Pract. 2010 Jun;10(2):122-4. doi: 10.1016/ j.jebdp.2010.02.014. Silver diamine fluoride (SDF) may be better than fluoride varnish and no treatment in arresting and preventing cavitated carious lesions. Beltrán-Aguilar ED(1).
63. Dent Today. 2010 Feb;29(2):130, 132-3. Leave decay in my cavity? You must be kidding! Knight GM(1), McIntyre JM, Craig GG, Mulyani.
64. J Am Chem Soc. 2010 Feb 10;132(5):1476-7. doi: 10.1021/ja909806t. Silver dendrites from galvanic displacement on commercial aluminum foil as an effective SERS substrate. GutésA(1), Carraro C, Maboudian R.
65. Braz Oral Res. 2009 Jul-Sep;23(3):296-301. In vitro evaluation of fluoride products in the development of carious lesions in deciduous teeth. SantosLdeM(1), Reis JI, Medeiros MP, Ramos SM, Araújo JM.
66. AcadPediatr. 2009 Nov-Dec;9(6):404-9. doi: 10.1016/j.acap. 2009.09.001. An examination of the EOC 5030, Rev 05 03/01/16 advances in science and technology of prevention of tooth decay in young children since the Surgeon General's Report on Oral Health. MilgromP(1), Zero DT, Tanzer JM.
67. Evid Based Dent. 2009;10(3):68. doi: 10.1038/sj.ebd.6400661. Silver lining for caries cloud? DeeryC(1).
68. J Org Chem. 2009 Nov 6;74(21):8232-42. doi: 10.1021/jo901725k. 5(6)-anti-Substituted-2-azabicyclo[2.1.1]hexanes: a nucleophilic displacement route. KrowGR(1), Edupuganti R, Gandla D, Choudhary A, Lin G, Sonnet PE, DeBrosse C, Ross CW 3rd, Cannon KC, Raines RT.
69. Dent Mater. 2010 Jan;26(1):29-34. doi: 10.1016/j.dental. 2009.08.011. Effects of ammonium hexafluorosilicate concentration on dentin tubule occlusion and composition of the precipitate. SugeT(1), Kawasaki A, Ishikawa K, Matsuo T, Ebisu S.
70. J Dent Res. 2009 Jul;88(7):644-7. doi: 10.1177/0022034509338671. Efficacy of silver diamine fluoride for Arresting Caries Treatment.YeeR(1), Holmgren C, Mulder J, Lama D, Walker D, van PalensteinHelderman W.
71. Quintessence Int. 2009 Feb;40(2):155-61. Inability to form a biofilm of Streptococcus mutans on silver fluoride- and potassium iodide-treated demineralized dentin. Knight GM(1), McIntyre JM, Craig GG, Mulyani, Zilm PS, Gully NJ.
72. J Dent Child (Chic). 2009 Jan-Apr;76(1):28-33. Effect of silver diammine fluoride on incipient caries lesions in erupting permanent first molars: a pilot study. Braga MM(1), Mendes FM, De Benedetto MS, Imparato JC.
73. Journal of Advanced Oral Research / Jan-Apr 2014 / Vol. 5 No.1. Silver Diamine Fluoride: A Review and Current Applications. Shalin Shah1, Vijay Bhaskar2, Karthik Venkatraghavan3, Prashant Choudhary4, Ganesh M.5, Krishna Trivedi6
74. International Dental Journal 2012; 62: 47–51. doi: 10.1111/j.1875-595X.2011.00088.x. Paradigm shift in the effective treatment of caries in schoolchildren at risk. Valdeci E. dos Santos Jr, Fla´ via M. N. de Vasconcelos1, Andre´a G. Ribeiro and Aronita Rosenblatt
75. J Dent. 2015 May 30. pii: S0300-5712(15)00124-4. doi: 10.1016/j.jdent.2015.05.006. A randomized clinical trial on arresting dentine caries in preschool children by topical fluorides -18 month results. Duangthip D, Chu CH, Lo CM
76. Parental Acceptance of the Use of Diamine Silver Fluoride in Children Aged 0 to 3 Years in the City of Cascavel, PR, Brazil Thaisa Cezária TRICHES, Mabel Mariela Rodríguez CORDEIRO, Juliana Garcia Mugnai Vieira SOUZA, Eduardo Karam SALTORI, Beatriz Helena Sottile FRANÇA
77. Pulp response to high fluoride releasing glass ionomer, silver diamine fluoride, and calcium hydroxide used for indirect pulp treatment: An in-vivo comparative study. AtishKorwar, Sidhartha Sharma, Ajay Logani, and NaseemShahContempClin Dent. 2015 Jul-Sep; 6(3): 288–292.
78. Efficacy of Silver Diamine Fluoridefor Caries Reduction in PrimaryTeeth and First Permanent Molarsof Schoolchildren:36-month Clinical Trial. J.C. Llodra, A. Rodriguez, B. Ferrer,V. Menardia, T. Ramos, and M. Morato. J Dent Res 84(8):721-724, 2005 EOC 5030, Rev 05 03/01/16
79. The evidence base for professional and self-care prevention - caries, erosion and sensitivity. Twetman S. BMC Oral Health. 2015;15 Suppl 1:S4. doi: 10.1186/1472-6831-15-S1-S4. Epub 2015 Sep 15.
80. Root Caries in Older Adults. Gregory D, Hyde S. J Calif Dent Assoc. 2015 Aug;43(8):439-45.
81. Silver diamine fluoride and glass ionomer differentially remineralize early caries lesions, in situ. Nantanee R, Santiwong B, Trairatvorakul C, Hamba H, Tagami J. Clin Oral Investig. 2015 Sep 23.
82. The effectiveness of the biannual application of silver nitrate solution followed by sodium fluoride varnish in arresting early childhood caries in preschool children: study protocol for a randomised controlled trial. Chu CH, Gao SS, Li SK, Wong MC, Lo EC. Trials. 2015 Sep 25;16(1):426. doi: 10.1186/s13063-015-0960-2
83. Prevention of secondary Caries by silver diamine fluoride. Mei ML, Zhao IS, Ito L, Lo EC, Chu CH. Int Dent J. 2015 Dec 22. doi: 10.1111/idj.12207
84. An alternate technique of care using silver fluoride followed by stannous fluoride in the management of root caries in aged care. Deutsch A. Spec Care Dentist. 2015 Dec 21. doi: 10.1111/scd.12153.
85. Caries remineralisation and arresting effect in children by professionally applied fluoride treatment - a systematic review. Gao SS, Zhang S, Mei ML, Lo EC, Chu CH. BMC Oral Health. 2016 Feb 1; 16(1), 12.
86. Effects of Silver DIamine Fluoride and Potassium Iodine Treatment on Secondary Caries Provention and Tooth Discolouration in Cervical Glass Ionomer Cement Restoration. Zhao et All, 2017. [link]